Authentication and Authorization Modules for Open Messaging Interface (O-MI)

With the constant rise of new technology, developments in the fields of computer science, wireless networks, storage capabilities and sensing possibilities along with the demand for continuous connectivity have lead to the formation of the Internet of Things (IoT) concept. Today, there are numerous organizations working on the IoT technology aimed at developing smart products and services. Each company proposes its own methods directed for a particular field of industry thus, it ends up with having several protocols. This has poorly followed the concept of a unified system. The Open Group attempted to address this issue by proposing Open Messaging Interface (O-MI) and Open Data Format (O-DF) protocols and claimed O-MI to be an IoT messaging standard as that of HTTP for world-wide-web (WWW). The proposed protocols have been designed to ensure robust development, data standardization, and required security level. However, the security model needs to be upgraded with the recent security techniques. This thesis attempts to specify appropriate authentication and authorization (access control) mechanisms that manage various consumers and provide functionalities that fit into O-MI/O-DF standards. The thesis first discusses several challenges regarding IoT security and then different authentication and authorization techniques available today. It then describes in detail the design decisions and implementation technicalities of the autonomous services created for the reference implementation of O-MI and O-DF

Mine Awareness Education in the Republic of Yemen

The Republic of Yemen is situated on the southern tip of the Arabian Peninsula between the Gulf of Aden and the Red Sea. It is a country of beautiful scenes and architecture. The Republic of Yemen has 17 million people and is growing at a rate of 3.7 percent annually

Impact of Ramadan fasting on thyroid status and quality of life in patients with primary hypothyroidism: A prospective cohort study from Karachi, Pakistan

Objective: Ramadan is the ninth month in the lunar calendar, during which Muslims fast from predawn to sunset and major changes occur in their dietary, sleep, and physical activity patterns. Most patients with hypothyroidism are unable to comply with the proper timings of levothyroxine (LT4) administration. The objective of the study was to determine the change in thyroid-stimulating hormone (TSH) level and quality of life (QOL) before and after Ramadan in patients with primary hypothyroidism.Methods: This prospective cohort study included adult patients on stable doses of LT4 who fasted for at least 20 days during the month of Ramadan in the Islamic year 1437 Hijri (June/July 2016). Baseline characteristics and TSH levels were recorded on all consenting patients within 6 weeks prior to Ramadan. Post-Ramadan TSH was tested within 1 to 2 weeks after Eid-ul-Fitr.Results: During the study period, 64 patients with hypothyroidism were enrolled, of which 58 were female. The mean age of participants was 44.2 ± 13.2 years. Average daily dose of LT4 was 95.3 ± 35.4 μg. On average, patients fasted for 26.5 days and missed a dose of LT4 on 1.27 days. Mean TSH pre-Ramadan was 2.37 ± 1.35 mIU/L, and post-Ramadan, it was 4.69 ± 3.87 mIU/L. Mean difference between TSH pre- and post-Ramadan was 2.32 ± 3.80 mIU/L ( P\u3c.001). However, the difference in TSH was not significantly different between those who were compliant with meals and LT4 interval versus those who were not (compliant, 2.04 mIU/L; noncompliant, 3.15 mIU/L; P = .30). Overall, an increase in QOL scores in the domains of physical health, psychological health, and social relationships was observed after Ramadan.Conclusion: We observed statistically significant changes in TSH concentrations after the month of Ramadan in hypothyroid patients who fasted. The change in TSH was not affected by timing of LT4 intake and interval from meal

Prognosis of Severe Covid-19 patients after treatment with Therapeutic Plasma Exchange (TPE)

OBJECTIVE: To demonstrate the effective role of plasmapheresis in the treatment of Cytokine Release Syndrome associated with severe Covid 19 pneumonia. INTRODUCTION: Covid-19 disease is a deadly contagious disease with milder symptoms to a more severe form with acute respiratory failure, septic shock leading to even death. Literature study showed  that  in severe  Covid-19  patients, a hyper-inflammatory response  to  initial  infection could accelerate  to  severe  hyper-cytokinaemia that  could  lead to  an  underlying endothelial  dysfunction and multiple organ dysfunction. Thus, removal of these inflammatory cytokines by Therapeutic Plasma Exchange is considered to be an essential part of the treatment of critically ill patients in order to improve their survival rates. METHODOLOGY:  Retrospective observational study which included 150 RT-PCR positive patients admitted in Covid ITC, from the time period of 1st February 2021 to 31st July 2021 –removed for blind review---Data was analyzed using SPSS software version 16. Frequencies were calculated along with mean and standard deviation. Chi square and ANOVA test was applied to the data. P value <0.05 was considered statistically significant. Linear regression study was applied to predict the prognosis. RESULTS: Out of 150 patients, 51 patients (34%) were of severe ARDS category of whom 13 (25.5%) developed Cytokine Release Syndrome. They received plasmapheresis therapy subsequently and 7 out of those 13 (53.8%) patients got improved. P- value was found to be significant ( <0.05). Overall, the mortality rate was low with 120/150 (80%) getting discharged successfully. CONCLUSION:  Our findings suggest that Therapeutic plasma exchange is beneficial in Cytokine storm caused by SARS-CoV2 removing the inflammatory cytokines and improving symptoms, thereby, avoiding intubation. KEY WORDS: , Therapeutic plasma exchange, Hypercytokinaemia, Cytokine Release Syndrom

PHARMACOKINETICS AND BIOAVAILABILITY OF ORTHOSIPHON STAMINEUS ETHANOLIC EXTRACT AND ITS-NANO LIPOSOMES IN SPRAGUE-DAWLEY RATS

Objective: This study aimed to perform pharmacokinetic profile of rosmarinic acid (RA), sinensitin (SIN), eupatorin (EUP) and 3΄-hydroxy-5,6,7,4΄-tetramethoxyflavone (TMF) in Orthosiphon stamineus ethanolic extract (OS-E) and its nanoliposomes (OS-EL) after oral and intravenous administration in Sprague-Dawley rat's plasma by developing and validating a high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection.Methods: An isocratic elution program consisting of methanol: tetrahydrofuran: water (0.1% H3PO4) mixture in the volume ratio 55: 5: 40 on Nucleosil C18 column (250 × 4.6 mm internal diameter × 5 µm particles size) was applied. The current study followed a two-ways crossover study design. OS-E and OS-EL were administered orally at 1000 and 500 mg/kg, respectively. They were also administered intravenously at 250 mg/kg via the tail vein.Results: The HPLC-UV method was successfully developed and validated for simultaneous determination of major chemical constituent from OS-E and OS-EL in rat's plasma. The method recorded the mean recoveries from extraction were between 91.39 and 100.32%. With regards to the intravenous administration of OS-EL, all four marker compounds appeared to be poorly distributed and cleared slowly from the body compared to OS-E. Whilst in oral administration of OS-EL, the bioavailability of all marker compounds were higher than OS-E due to higher solubility of encapsulation in phospholipids.Conclusion: The higher solubility and bioavailability of OS-EL may contribute to encapsulation in phospholipids

Role of Dexmedetomidine by Improving Sleep Quality and Pain Control in Covid-19 Patients

OBJECTIVE: To demonstrate the effective role of Dexmedetomidine as a sedative and analgesic agent in Covid-19 patients when used in conjunction with the established treatment of Acute Respiratory Distress Syndrome.  INTRODUCTION: Covid-19 disease is a deadly contagious disease with milder symptoms to a more severe form with acute respiratory failure, septic shock leading to even death. Literature study shows High Flow Nasal Oxygen therapy and prolonged prone position sessions to be beneficial in the treatment of ARDS, however, to facilitate those sessions, a sedative and anxiolytic agent must be added in the treatment. Therefore, this study was conducted to document the beneficial role of dexmedetomidine as a sedative agent.  METHODOLOGY: Retrospective observational study which included 150 PCR positive patients admitted in Covid ITC, from 1st February 2021 to 31st July 2021 residing in the premises of PAF Air Base, Mushaf, Sargodha. Data was analyzed using SPSS software.   RESULTS: Out of 150 patients, 120 (80%) were treated with High Flow Nasal Oxygen (HFNO), Dexmedetomidine infusion (DEXME) and long periods of prone position (PP) sessions. Among these 120 patients, 88 (73.3%) were discharged while 32 (26.67%) patients died of which 7 (21.875%) died while being on HFNO therapy and 25 (78.125%) patients were intubated. DEXME infusion was found to have a positive outcome (P-value <0.005) in the treatment of moderate to severe ARDS.  CONCLUSION: Our findings suggest that DEXME infusion is beneficial in moderate to severe ARDS caused by SARS-CoV2  when given along with HFNO therapy and prolonged PP sessions, thereby, avoiding intubation. 

Network Qos architecture

There is huge growth in internet recently. This growth is started initially at slow rate with limited number of application, However as the time progresses the nehvork has expanded in term of users and applications, This expansion dictated a alteration and modification of the original protocol to enable higher Quality of service. This chapter provides tan over view about QoS requirement, architecture and mobility suppor

Femtocell network synchronization

Currently, Femtocell technology emerged for cellular wireless networks, which has rapidly engrossed cellular industry. The principle of femtocell to the mobile operators is to reduce cost and improve signal quality in indoor coverage which is also considered a possible path to the fixed-mobile convergence (FMC) goal. Femtocell extends network coverage and delivers high-quality mobile services inside residential and business buildings through broadband network i.e. ADSL. Femtocell access point (FAP) or home base station (HBS) intends to serve small number of users i.e. 4 users and covers about 30 meter square similar to existing WiFi access points. However, femtocell introduces new challenges to the telecom industries in terms of handoff between femto and macrocells, interference management, localization and synchronization. Among all 0 f these challenges, synchronization is considered corner stone for proper working for femtocell. The problematic issue in femtocell synchronization is that all the data and control traffics travel through IP broadband network. The IP broadband network is usually owned and managed by third party and not by the mobile operator, which is complicated the synchronization. Unsynchronized FAPs may cause harm interferences and wrong handover dictions. In this study we investigate and overview the current femtocell synchronization techniques and compare between them. Possible improvements and recommendation for each method is identified. Future research areas and open issues were also discussed

Technology transfer in developing countries

Technology has a great effect on productivity, wealth, health and life style of individuals and countries. Due to the rapid growth of technologies and poor infrastructure in developing countries they feel that they are far behind developed countries and Technology transfer has become a great issue of concern for researchers, companies and policy makers. However, the technology transfer is very challenge process that contains enormous barriers and constrains such as lack of infrastructure and educational development of the people. One of main challenges faced by Technology transfer is to have a clear process by which to identify the most suitable technology from out of several alternative technologies. This paper present and discusses technology, transfer process, channels, challenges and barriers

Mobility management enhancement in smart cities using software defined networks

Achieving sustainability in cities relies on effective mobility management (MM) that serves current and future generations. It involves establishing an inclusive transportation system to address many issues, like traffic congestion, air pollution, and greenhouse gas emissions. Beyond environmental concerns, robust mobility management has social and economic advantages, fostering improved access to vital services like healthcare, education, and employment. Softwaredefined networking (SDN) presents a viable solution for enhancing MM within networks. Unlike traditional setups, SDN merges MM through a programmable control plane, streamlining network configurations and enabling features like handover, load balancing, and quality of service (QoS). The utilization of SDN technology extends to various facets of sustainable city networks, encompassing areas like network security, performance optimization, big data processing, energy efficiency, emergency management, carbon emissions reduction, intelligent services, and MM in vehicular networks. Despite the advantages of SDN-based mobility management, it’s crucial to acknowledge the challenges and limitations posed by traditional MM methods that SDN aims to overcome. The paper explores SDN’s potential in sustainable cities, focusing on how it can transform mobile device management, support various networking technologies, and evaluate the impact of SDN methods on existing MM systems, considering factors like scalability and compatibility. The paper asserts that SDN-based MM has substantial potential for promoting sustainable urban development. By centralizing control, adapting to changing conditions, and optimizing resource allocation, SDN can contribute to reduced energy consumption, lower carbon emissions, and more efficient urban mobility. It emphasizes the importance of addressing potential drawbacks to ensure successful implementation in sustainable cities